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The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine.
In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration. Seizures should be controlled with benzodiazepines or, if these are ineffective, other anticonvulsants (e.g. phenobarbital, phenytoin). Physostigmine is not recommended except to treat life-threatening symptoms that have been unresponsive to other therapies, and then only in close consultation with a poison control center. Pharmacologic similarities among the tricyclic drugs require that certain withdrawal symptoms be considered when FLEXERIL is administered, even though they have not been reported to occur with this drug.
Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively.
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Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Do not use Flexeril if you have taken an MAO inhibitor in the past 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. This medication is not recommended for use in older adults because they may be at greater risk for side effects while using this drug.
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It’s believed to work by attaching to a receptor or protein in the brain called the alpha-2 receptor, which reduces the release of substance P in your brain and spinal cord. Substance P is a chemical that helps increase pain signals to and from the brain. The most common side effects of Flexeril are drowsiness, dizziness, headache, and dry mouth.
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Cyclobenzaprine is a centrally acting skeletal muscle relaxant structurally related to tricyclic antidepressants. Cyclobenzaprine is a tricyclic amine salt that works in the central nervous system (CNS) as a depressant that reduces muscle hyperactivity. Clinical indications for cyclobenzaprine are described below. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
NDC Crossover Matching brand name “Cyclobenzaprine Hydrochloride” or generic name “Cyclobenzaprine Hydrochloride”
Talk to your provider if you experience any bothersome side effects. Depending on the type of muscle relaxer, there are different forms in which you can take them, such as tablets, capsules, solutions or injections. Baclofen is considered the first-line treatment for spasticity, especially muscle relaxer flexeril for adults who have spinal cord injuries. Both drugs also interact with certain high blood pressure drugs. Skelaxin and Flexeril can potentiate the effects of alcohol, barbiturates, and other CNS depressants, such as benzodiazepines, opioids, antihistamines, and sedative-hypnotics.
- When these drugs interact, it can worsen side effects like drowsiness and dizziness.
- Monitoring of plasma drug levels should not guide management of the patient.
- Here are examples of other drugs that may interact with tizanidine and cyclobenzaprine.
- For these reasons, in the elderly, cyclobenzaprine should be used only if clearly needed.
- However, these medications aren’t the first-line therapy for the treatment of pain or spasms.
- Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke.
If your dose is different, do not change it unless your doctor tells you to do so. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Take this medication by mouth with or without food as directed by your doctor, usually once daily. Doing so can release all of the drugs at once, increasing the risk of side effects. In a pharmacokinetic study of sixteen subjects with hepatic impairment (15 mild, 1 moderate per Child-Pugh score), both AUC and Cmax were approximately double the values seen in the healthy control group. Based on the findings, FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with the 5 mg dose and titrating slowly upward. Due to the lack of data in subjects with more severe hepatic insufficiency, the use of FLEXERIL in subjects with moderate to severe impairment is not recommended.
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In case of acute cyclobenzaprine overdose, emergency medicine physicians and triage nurses should stabilize the patient. If EKG demonstrates QRS prolongation, the clinician should initiate sodium bicarbonate therapy. In severe overdose, ventricular arrhythmias and seizures may require MICU-level of care under the supervision of a critical care physician. As discussed above, the clinician should consider contacting the poison control center in refractory cases.